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MOUNT LAUREL, N.J.--( / )--Diversified biotechnology company CCM Biosciences (CCM Bio) announced the launch of its business unit (5Prime) focused on the development and application of proprietary technology in the domain of DNA biotechnology. 5Prime’s includes multiple patent-protected, globally commercialized compositions and methods for molecular cloning, next-generation DNA sequencing and molecular diagnostics.

5Prime has two focus areas: 1) in vitro diagnostic (IVD) tests: a wide array of for targeted cancer, rare disease, and prenatal/preimplantation diagnostics, developed using the droplet digital Polymerase Chain Reaction (ddPCR) and Next-Generation Sequencing (NGS) methodologies, which accompany the personalized medicine therapeutic (Rx) pipeline of CCM Bio; 2) synthetic biology: that improve upon the enzymes used in IVD tests, in PCR reagents, and also in enzymatic DNA/RNA synthesis.

Proven technology behind market-leading DNA sequencing products and diagnostic tests; including one of the 5 highest revenue-generating technologies invented in the history of Princeton University

Focus areas 1 and 2 are based on the originating in the PhD thesis work of Co-Founder and CEO Dr. Raj Chakrabarti at Princeton University. According to the Princeton University Office of Technology Licensing, patents in this portfolio, which are now controlled by 5Prime, are among the top 5 revenue-generating patents in the history of the university, having been such as Celera Diagnostics, Quest Diagnostics, Abbott, New England Biolabs, and Toyobo Life Sciences. Diagnostic tests and products based on the company’s intellectual property include the XSense test from Quest Diagnostics, which is the leading DNA-based carrier screening test for autism (Fragile X syndrome); and the Q5 polymerase kit marketed by New England Biolabs, which is the leading high-fidelity polymerase kit for DNA sequencing.

In the context of molecular diagnostics, NGS is typically applied to diagnose in high-throughput the patterns of DNA mutations in genes. A related method called RNA-Seq, which applies NGS to RNA rather than DNA to measure real-time gene expression levels, has emerged as a foundation for modern personalized medicine. However, a notorious difficulty in both traditional NGS and RNA-Seq is sequence bias, which results in inaccurate estimates of the relative copy numbers of different genes and associated disease-causing mutations, and which has limited the transformative potential of these methods. ddPCR is a sensitive method for diagnosing mutations in specific disease-associated genes that is also limited by problems of sequence bias.

5Prime’s technology enables the of nearly any DNA or RNA sequence to overcome sequence bias in nucleic acid amplification and associated diagnostic methods like NGS and ddPCR, the global markets for which were valued at $10B and $6B, respectively, in 2022 and expected to surpass $44B and $14B, respectively, by 2032. Its state-of-the-art synthetic biology platform for polymerase enzyme engineering generates proprietary polymerases with optimal properties for NGS or PCR-based diagnostic tests, by applying . In addition, the company’s technology platform applies proprietary nonaqueous media and computational systems biology methods in conjunction with such enzymes to dramatically improve nucleic acid polymerization and amplification efficiency.

About CCM Biosciences

CCM Biosciences, Inc. is a biotechnology company dedicated to discovering and developing novel drugs - including small molecules, gene therapies, biologics, and nanomedicines - as well as associated companion diagnostics. CCM Bio’s patented molecular discovery platforms were developed at Chakrabarti Advanced Technology, a privately funded R&D institute founded in 2010 with scientists in the US, France and India and with publications in leading scientific journals including PNAS, Nucleic Acids Research, American Chemical Society journals and Nature Publishing Group journals. CCM Bio is partnered with the global chemical and pharmaceutical services company PMC Group, Inc. for fully integrated discovery, development and manufacturing of drugs and diagnostics.

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RAS AL KHAIMAH, UAE--( / )--The American University of Ras 임상동포커 밴쿠버올림픽김연아 Al Khaimah (AURAK) bachelors of science degree programs in computer science, industrial engineering, and mechanical engineering have been accredited by the Computing and Engineering Accreditation Commissions (CAC and EAC) of ABET, the global accreditor of college 흥부넷 손연재섹시댄스 and 흥부넷 현아장현승트러블메이커뮤비 university 흥부넷 현아이기광임신 programs in applied and natural science, computing, engineering, and engineering technology.

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The American University of Ras Al Khaimah, United Arab of Emirates (UAE) is a 흥부넷 일본코스프레 government-owned institution of higher education which provides an integrated North American-style education. It is accredited by the Ministry of Higher Education and Scientific Research in UAE and offers a total of 22 undergraduate and graduate programs across a 임상동포커 wide range of disciplines. The Southern Association of Colleges and Schools Commission on Colleges (SACSCOC) awarded the institution candidacy status in July 2017.

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