라이브경마<- 바로가기 INGELHEIM, GERMANY--( / ) November 15, 2017 -- Boehringer Ingelheim announced results from two sub-analyses of the phase III RE-VERSE AD™ study.[1,2] The sub-analyses evaluated the safety and efficacy of idarucizumab (marketed as Praxbind®) in reversing the anticoagulant effect of dabigatran etexilate (marketed as Pradaxa®) in patients in diverse emergency situations. These include those with acute bleeding or requiring an urgent surgery or procedure, such as an orthopedic, vascular or abdominal procedure. The analyses were presented at the American Heart Association (AHA) Scientific Sessions 2017 in Anaheim, California, USA. They provide further insights on the use of idarucizumab in patients with gastrointestinal (GI) bleeding and in those with a need for urgent surgery or intervention.
“The RE-VERSE AD study has demonstrated that idarucizumab can reverse the anticoagulant effect of dabigatran within minutes, allowing physicians to quickly initiate emergency interventions for patients who need urgent surgery or are experiencing uncontrollable bleeding,” said Charles Pollack, M.D., lead investigator of RE-VERSE AD, Professor of Emergency Medicine, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, USA. “These new analyses further reinforce the potential for idarucizumab to enhance care for people living with atrial fibrillation.”
One of the sub-analyses focused on patients with GI bleeding,[2] the most common type of bleeding event among patients who were enrolled in the study due to acute bleeding. Of the 137 patients enrolled with a GI bleed, complete reversal of the anticoagulant effect of dabigatran was observed in more than 95 percent of patients. The median time to cessation of bleeding post-idarucizumab administration was less than three hours when the location of the GI bleed was known and 6.4 hours when the location was unknown.
Mortality and thromboembolic event rates for patients with a GI bleed were consistent with the overall findings of RE-VERSE AD™. In the sub-analysis, as presented in the abstracts, at 90 days, there were low thromboembolic event rates of 5.1 percent in patients with a GI bleed, compared to 6.3 percent in non-GI bleed patients. Mortality in the first five days following administration was 6 percent in patients with a GI bleed, compared to 9 percent in non-GI bleed patients. At 90 days, mortality rates were 16 percent and 23 percent, respectively.[2]
Also presented at AHA were updated results assessing periprocedural bleeding in patients requiring an urgent procedure, such as an emergency surgery.[1] Idarucizumab rapidly and completely reversed the anticoagulant effect of dabigatran in approximately 98 percent of patients based on diluted thrombin time (dTT). The median time between administration of idarucizumab and start of surgery was 1.7 hours for patients requiring abdominal procedures, 1.9 hours for orthopaedic procedures, 1.4 hours for vascular procedures, 1.3 hours for drainage procedures and 1.2 hours for catheter procedures. Among these patients, periprocedural bleeding was assessed as normal (if anticoagulation were absent) in more than 92 percent of patients, across all surgery types. Among patients needing emergency surgery, none were assessed as experiencing periprocedural bleeding that was severely abnormal (severe refractory hemorrhage). RE-VERSE AD™ is the only study to investigate anticoagulation reversal among patients requiring surgery.
“The RE-VERSE AD sub-analyses presented at the AHA Scientific Sessions provide insights in two highly relevant areas for patients and physicians,” said Professor Jorg Kreuzer, Vice President Medicine, Therapeutic Area Cardiovascular, Boehringer Ingelheim. “Accidents can happen in life, also to patients taking an anticoagulant. Knowing that a fast-acting reversal agent is available is very reassuring to patients and their treating physicians. That is why we continue our efforts to expand the global availability of idarucizumab, the reversal agent for dabigatran.”
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LONDON--( / ) October 16, 2018 -- The Year in Infrastructure 2018 Conference-- Bentley 가상화폐사용 로또당첨번호횟수 Systems, Incorporated, the leading global provider of comprehensive software solutions for advancing the design, construction, and operations of infrastructure, today announced the acquisition of leading pedestrian simulation software provider LEGION, based in London and supporting more than half of the world’s 40 largest transit agencies. The acquisition augments Bentley’s comprehensive modeling environment with collaborative digital workflows to explore and validate comparative simulations of pedestrian traffic scenarios.
LEGION’s pedestrian simulation application offers modeling capabilities of people’s interactions with each other and physical obstacles, and activities, including circulation and evacuations, within public spaces like railway stations, airports, sports arenas, tall buildings, and street level with vehicle interactions. Using LEGION simulation tools in collaborative digital 가상화폐사용 로또지점 workflows with Bentley’s 가상화폐사용 OpenBuildings Designer (formerly AECOsim Building 비추천야동사이트 LEGION’sarchitects, engineers and owners can 가상화폐사용 로또기록 consider pedestrian traffic in their conceptioneering of design alternatives. The newly announced 라이브경마 로또1등지역 OpenBuildings Station Designer will enable collaborative digital workflows to fully model pedestrian activities and journeys to and from trains, platforms, and through stations.
Santanu Das, senior vice president of design engineering for Bentley Systems, said, “Because pedestrian traffic and 라이브야마토릴게임 Santanuare major concerns for infrastructure planning and operations, collaborative digital workflows for 가상화폐사용 pedestrian 가상화폐사용 로또당청금 simulation need to be prioritized during design. Taking advantage of LEGION’s innovative pedestrian modeling capabilities throughout Bentley’s comprehensive modeling environment will enable better decisions to improve pedestrian circulation, throughput, and overall safety. That’s a great example of 가상화폐사용 로또역대당첨번호 the collaborative digital workflows that our open applications, such as OpenBuildings, uniquely support.”
LEGION founder, Douglas Connor, said, “Pedestrian 라이브야마토릴게임 LEGIONshould be considered fundamental design criteria for infrastructure assets like train stations or airports which are intrinsically meant to serve the needs of 가상화폐사용 로또당첨확률계산 pedestrians. We’re excited to join with Bentley to provide designers, engineers, and owners with pedestrian simulation applications that are integrated with market leading design modeling offerings. Next, we can advance LEGION’s “Science in Motion” vision to incorporate pedestrian simulation quite cohesively?from the strategic and capital planning of an infrastructure project, throughout its design, subsequent retrofits, and into asset operations.”
Samya Ghosh, head-urban space; regional director, transportation (Europe, Middle East, India, and Africa) for premier, fully integrated global infrastructure firm AECOM, said, “The urban space team of AECOM, based in the UK, has been using LEGION software for various crowd modeling projects for more than 가상화폐사용 로도복권 10 years?in numerous national and international projects. The crowd modeling is primarily undertaken to provide an evidence base for wider evaluation of existing and proposed rail infrastructure, public realm, sports venue and major event planning, and 라이브경마 로또자동생성 design or refurbishment of large institutions. The LEGION software is widely accepted among clients for pedestrian micro-simulation modeling which our professionals use to analyze and inform designs and masterplans. In our recent projects, it has been increasingly important to integrate the pedestrian modeling with BIM and in this respect, I consider the merger of Bentley 라이브야마토릴게임 SamyaLEGION will open up a huge potential.”
About 가상화폐사용 연금복권하는법 바카라박물관 About라이브경마 연금식복권
Founded in 1997, LEGION is a world-leading developer of pedestrian 가상화폐사용 복권마감시간 simulation software. The scientifically validated software 캣툰 Foundedsimulates and analyzes people’s step-by-step journey 가상화폐사용 through rail/metro stations, stadia, shopping malls and airports. Designers and owners use it to model, test and deliver operational, commercial, footfall, wayfinding, crowd management, and safety strategies. LEGION simulation is based on extensive research of people’s behavior in real contexts. As it microscopically accounts for individual decision making, crowd 라이브경마 호주복권 formation and patterns of movement emerge naturally. More about LEGION.
About 가상화폐사용 먹튀sos AboutSystems
Bentley 가상화폐사용 복권게임 Systems is the leading global provider of software solutions to engineers, architects, geospatial professionals, constructors, and owner-operators for the design, construction, 라이브경마 로또번호당첨확인 먹튀sos Bentleyoperations of infrastructure. Bentley’s MicroStation-based engineering and BIM applications, and its 가상화폐사용 digital twin cloud services, advance the project delivery (ProjectWise) and the asset performance (AssetWise) of transportation and other public works, utilities, industrial and resources plants, and commercial and institutional facilities.
Bentley Systems employs more than 3,500 colleagues, generates annual revenues of $700 million in 170 countries, and has invested more than $1 billion in research, development, and acquisitions since 2012. From inception in 1984, the company has remained majority-owned by its five founding Bentley brothers. Bentley shares transact by invitation on the 가상화폐사용 NASDAQ Private Market; strategic 손빨넷 BentleySiemens AG has accumulated a non-voting minority stake.
Caption 라이브경마 로또스파 성인용품점창업 CaptionImage: 가상화폐사용 생방송주택복권추첨
LEGION’s pedestrian simulation applications offer modeling for scenarios such as interaction of pedestrians with each other and with physical obstacles, circulation and evacuations within public spaces like railway stations, airports, sports arenas, and tall buildings, and pedestrian 라이브경마 and 가상화폐사용 연금복권구입처 vehicle interactions.
Bentley, the Bentley logo, AECOsim 가상화폐사용 행운의로또 Building Designer, AssetWise, LEGION, 가상화폐사용 주택복권번호 MicroStation, OpenBuildings Designer, OpenBuildings Station Designer, and ProjectWise are either registered or unregistered trademarks or service marks of Bentley Systems, 가상화폐사용 Incorporated or one 라이브경마 of its direct or indirect wholly owned subsidiaries. All other brands and product names are trademarks of their respective owners.
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