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INGELHEIM, GERMANY & OXFORD, ENGLAND & LONDON--( / )--Boehringer Ingelheim and Enara Bio, today announced that they have entered into a strategic collaboration and licensing agreement to research and develop novel targeted cancer immunotherapies, leveraging Enara Bio’s Dark Antigen™ discovery platform. This new collaboration combines Boehringer Ingelheim’s approach to tackle cancer through pairing leading science with innovative immune-oncology platforms, such as oncolytic viruses and cancer vaccines, with Enara Bio’s expertise in cancer antigen identification. The aim is to provide potential new therapies for patients with difficult to treat lung and gastrointestinal cancers.

“We are excited to partner with Enara Bio as part of our mission to bring transformative new treatments to cancer patients,” said Jonathon Sedgwick, Ph.D., Senior Vice President and Global Head, Cancer Immunology & Immune Modulation Research, Boehringer Ingelheim. “We are advancing a unique pipeline of cancer cell-directed agents, immuno-oncology therapies and intelligent combination approaches to help combat cancer. Enara Bio’s unique discovery platform offers a novel and highly differentiated approach that will allow us to look beyond the known proteome to identify and characterize Dark Antigens to support the development of T-Cell Receptor (TCR)-directed immunotherapies and therapeutic vaccines. We believe this is a highly innovative and promising approach to the development of the next wave of cancer immunotherapies.”

Enara Bio’s proprietary Dark Antigen Platform Technology (EDAPT™) will be used to discover and validate novel Dark Antigens in up to three tumor types in the lung and gastrointestinal cancer space. The discovery of shared antigens could lead to the development of vaccines that can be readily utilized to help a broader group of cancer patients.

Dark Antigens represent a new class of cancer-associated antigens that derive from the genomic dark matter, or the portion of the human genome that is normally not expressed as protein. Dark Antigen-encoding sequences are usually silenced in healthy cells but are activated and presented on tumor cells. They are associated with specific cancer types and, importantly, are shared across patients. Since typically not visible to the immune system, they represent a large potential repertoire of novel antigens that can be developed as targets for new immunotherapies.

“We are extremely pleased to enter this strategic licensing agreement, our first major deal leveraging our pioneering Dark Antigen discovery and validation capabilities,” said Kevin Pojasek, President and CEO of Enara Bio. “Boehringer Ingelheim is an innovation-led company dedicated to producing breakthrough treatments with a significant focus on cancer. We are excited to build this relationship and are encouraged that Boehringer Ingelheim shares our view of the potential of Dark Antigens to be a source of important and unconventional targets for novel cancer immunotherapies. This agreement provides strong validation for our science and our approach to exploiting the cancer-associated antigenic repertoire derived from genomic dark matter and we look forward to a productive collaboration.”

This collaboration with Enara Bio is the latest of several strategic partnerships and acquisitions for Boehringer Ingelheim to build its cancer vaccine platform and provides important validation for Enara Bio’s Dark Antigen platform. The past acquisitions of ViraTherapeutics and AMAL Therapeutics’ vaccine modalities coupled with Enara Bio’s capabilities position Boehringer Ingelheim to develop sophisticated virus and vaccine modalities for its prime/boost vaccine platform.

Under the agreement, Boehringer Ingelheim has the option to license Dark Antigens discovered and validated by Enara Bio. Boehringer Ingelheim will also be responsible for all non-clinical and clinical development, as well as commercialization of associated cancer immunotherapies, including therapeutic vaccines and T-cell redirecting biologics. Enara Bio retains rights to use any discovered antigens for use in cell therapy-based products.

Enara Bio is eligible to receive an upfront payment, together with research/preclinical milestones and licensing fees for each tumor type that is explored. Enara Bio is also eligible to receive more than EUR 876 million in clinical, regulatory and commercial milestones, in addition to royalties on future product sales.

Please click on the following link for ‘Notes to Editors’:

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PARIS--( / )--A rare and beautiful 1936 Bugatti Type 57SC Atlantic was named the winner 안암동포커 of 글로리티비TV PARIS--(prestigious The Peninsula Classics Best of the Best Award today 안암동포커 xhamster at The Peninsula Paris 안암동포커 튜브브이 hotel.

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Speaking of the award’s legacy, The Hon. Sir Michael Kadoorie, Chairman of The Hongkong and Shanghai Hotels, Limited and co-founder of the award said, “My great hope is that we not only succeed in thrilling long-term car enthusiasts, but that this award 안암동포커 생중계카지노주소 will also ignite a 안암동포커 와와바카라주소 new-found passion for those just discovering the world of motoring.”

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“I 안암동포커 조개넷 second Peter’s thoughts - the other seven nominees were simply stunning, 안암동포커 bra which makes winning the 글로리티비TV “Ifeel even more special,” said Rob Walton, co-owner of the winning car. “What this award does is allow us to take a step back and admire the quality and beauty of the greatest classic cars in existence today. For an automotive fan like myself, it’s a joy.”

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Previously presented during Monterey Car Week, the award moved to Paris this year to be presented during the world-famous Retromobile event. The Bugatti was presented 안암동포커 서양 at 돈암2동포커 ThepornDude 로또연구소 Previously안암동포커 cams exclusive reveal party in The Peninsula Paris’ subterranean garage, following a private dinner. 안암동포커 자브넷

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The Peninsula Classics Best of the Best Award is among the top automotive awards in the world. In its milestone development of the international motoring world’s top accolade for most exceptional classic car, The Hon. Sir Michael Kadoorie, Chairman of The Hongkong and Shanghai Hotels, Limited, launched the award in 2015 with co-founders Christian Philippsen, William 안암동포커 7MM 아이러브사커 The“Chip” Connor and Bruce Meyer to celebrate the best of what defines the automotive world. Each founder shares a common passion and appreciation of fine motor cars, the preservation of their heritage 안암동포커 마블툰 and immaculate restoration projects. The award, sponsored by 안암동포커 티비고리 The Peninsula Hotels, brings together eight of the concours circuits’ elite best of show winners from around the globe.

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