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INGELHEIM, GERMANY--( / )--The European Commission (EC) granted a conditional marketing authorization for Boehringer Ingelheim’s spesolimab as first in class treatment for GPP flares in adults.[1] Spesolimab is a novel, selective antibody that blocks the activation of the interleukin-36 receptor (IL-36R), a signaling pathway within the immune system shown to be involved in the pathogenesis of GPP.[2, 4-7]

“The symptoms of GPP are devastating and cause immense pain as well as hospitalization during a flare. Increased GPP awareness that leads to accurate and faster diagnosis is one important step to improving the quality of life for people living with GPP,” said Frida Dunger Johnsson, Executive Director, IFPA. “Now with a specifically developed treatment, people living with GPP can be offered a new lease of life by effectively managing the impact of GPP flares.”

“We are delighted to be able to bring this much needed treatment to patients with GPP, whose options were incredibly limited until this year. This approval marks another significant milestone in the continued development of spesolimab in neutrophilic skin diseases which we are investigating in further clinical trials” commented Carinne Brouillon, Member of the Board of Managing Directors, responsible for Human Pharma, Boehringer Ingelheim. “Today’s news marks the first of what we hope will be a number of new treatment options from our accelerated late-stage portfolio with the potential to transform the lives of people for generations to come.”

The EC’s conditional approval of spesolimab is based on results from the pivotal EFFISAYIL® 1 Phase II clinical trial.[2] In the 12-week trial, patients experiencing a GPP flare were treated with spesolimab or placebo. Most patients at the outset of the trial had a moderate or severe pustulation of the skin. After one week, 54% of patients treated with a single dose of spesolimab showed no visible pustules compared to placebo (6%).[2] Adverse events were reported in 66% of patients treated with spesolimab and 56% of those receiving placebo after one week.[2] Infections were reported by 17% and 6% of patients in the spesolimab and placebo groups respectively (at week one).2 Serious adverse events were reported in 6% of patients treated with spesolimab (at week one).[2]

People living with GPP often do not receive a correct or timely diagnosis and may have their symptoms identified as other forms of psoriasis. A Global Delphi Consensus Project classified GPP as phenotypically, genetically, immunologically and histopathologically distinct from psoriasis vulgaris / plaque psoriasis based on a systematic literature review.[3] The growing list of regulatory approvals for spesolimab for the treatment of GPP flares underlines that the Delphi panel’s vision of improved diagnosis and treatment for people with GPP is increasingly achievable.

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SEOUL--()--Schneider Electric, the leader in the digital transformation of energy management and automation, has launched the Zero Carbon Project. Under the new initiative, the company 노출 유인나성형전사진 will partner with its top 1,000 suppliers - which represent 70% of Schneider’s carbon emissions - to halve their operations’ CO2 emissions by 2025. The initiative is part of Schneider’s 2021-2025 sustainability goals and is a concrete step towards limiting the rise in the average global temperatures to 1.5°C 노출 박한별화보 or less by 2100, as targeted 노출 박한별 by the 오피러브 SEOUL--()--SchneiderAgreement.

Under the program, Schneider will provide tools and resources to program participants to help them set and achieve their own carbon reduction targets. Suppliers will be first encouraged to quantify their CO2 emissions using the company’s digital tools. Suppliers will then use that data to set goals and strategies for emissions reduction. Suppliers will 신문로2가맞고 c컵 also work towards their goals through 노출 요즘중학생 decarbonization initiatives such as energy efficiency or renewables. The Zero Carbon Project will enable best practice exchange with peers and partners to access other innovative solutions for decarbonization.

The program will be supported by Schneider’s Energy 노출 & Sustainability Services division, which has partnered 노출 on similar supply chain decarbonization initiatives with its corporate clients, including Walmart, GSK, and the global Sustainable Apparel Coalition.

“The challenges posed by climate change are something we urgently need 해태 “Thetackle together,” said Olivier Blum, Chief Strategy and Sustainability Officer. “Schneider aims to reduce scope 3 emissions by 35% by 2030, but we can’t make this journey alone and we 노출 아이유슴골 encourage suppliers to join us as they are an integral part of our ecosystem. We offer to share our expertise and experience with them on how they can decarbonize their operations leveraging our range of Sustainability Consulting Services 신문로2가맞고 엄빠주의이야기 and digital EcoStruxureTM or other third-party solutions.”

For many organizations, reducing supply chain emissions can be one 노출 yes속옷화보 of the most challenging aspects of decarbonization, but also one of the most important priorities, since a 888스포츠중계 Forof organizational emissions can be found in the Scope 3 category (which includes all other indirect emissions that occur in the company's value chain.

“We’ve been actively reducing the carbon footprint of our supply chain. Through the use of our EcoStruxureTM platform, we managed to reduce energy consumption in our plants and distribution centers by 노출 스타킹써니성대모사 more than 10% every 3 years for the past 12 years. We currently operate 30 zero-emission sites, and more than 120 others will be added to the list in the next 5 years,” said Mourad Tamoud, Schneider Electric’s Chief Supply Chain Officer. “Our entire supplier network accounts for emissions of over 7 million CO2 tons per year, and we need them to take an active role, in partnership with us, if we are to make a meaningful reduction in our carbon footprint.”

Earlier this year, Schneider Electric was recognized by Corporate Knights as the most sustainable corporation in the world. The ranking was the result of more than 15 years of work by the company 노출 to refine and progress its sustainability strategy. Schneider has also been 노출 최은정몸매 recognized as a leader in energy management as the #1 Energy Service Company (ESCO) and in renewable energy as the RE100’s inaugural Clean Energy Trailblazer winner (2020). 노출 띠별운세 The company also debuted its corporate 먹튀공원 EarlierChange Advisory and Supply Chain Decarbonization services in February. To learn more, visitKorea Newswire distributes your news across every media channels through the industry’s largest press release distribution network