허리테크닉 INGELHEIM, GERMANY--( / )--Boehringer Ingelheim today announced that the SENSCIS® trial met its primary endpoint: reduction in the annual rate of decline in forced vital capacity (FVCa) in patients with systemic sclerosis associated interstitial lung disease (SSc-ILD). Results show that nintedanib slows the loss of pulmonary function in patients with SSc-ILD compared to placebo. Patients taking nintedanib showed a 44% reduction in the rate of decline of their lung function, measured in FVC assessed over 52 weeks[1]. These new data were today published in the New England Journal of Medicine (NEJM) and presented to the medical community at the American Thoracic Society (ATS) International Conference, in Dallas, USA.
SENSCIS® is the largest randomised controlled trial to be conducted in patients with SSc-ILD, a disease for which there are currently no approved treatments.[1,3,4] Results also showed that nintedanib had a safety and tolerability profile similar to that observed in patients with idiopathic pulmonary fibrosis (IPF)[1], with the most common adverse event being diarrhoea. Nintedanib is already approved in more than 70 countries for the treatment of IPF. These trial results formed the basis of the application for regulatory approval of nintedanib in SSc-ILD that was filed with the FDA and EMA by Boehringer Ingelheim in the first quarter of 2019. The FDA recently granted priority review to the supplemental application for nintedanib in SSc-ILD. The regulatory submissions are part of the company’s ongoing commitment to improving the lives of people living with pulmonary fibrosis, in particular those affected by rare diseases with a high level of unmet need.
Systemic sclerosis, also known as scleroderma, is a rare incurable autoimmune disease affecting connective tissue.[3,4,5] It can cause scarring (fibrosis) of the skin as well as major organs such as the heart, lungs, digestive tract and kidneys and can have life-threatening complications.[2,3] Approximately 25 percent of patients develop significant pulmonary involvement within three years of diagnosis.6 When SSc affects the lungs it can cause interstitial lung disease (ILD), known as SSc-ILD.[2,3] It is a key driver of mortality among people with SSc, accounting for approximately one third of deaths.[7,8]
SENSCIS®, a Phase III double-blind, randomised, placebo-controlled trial, involved 576 patients across more than 32 countries. The primary endpoint was the annual rate of decline in FVC in mL over 52 weeks.[1] At the end of the 52-week trial, patients receiving nintedanib had an adjusted annual rate of decline in FVC (mL/year) of -52.4 with nintedanib, versus -93.3 with placebo (absolute difference 41.0mL/year [95% CI 2.9, 79.0]; p=0.04). This corresponds to a relative difference of 44% reduction in lung function decline[1], similar to the results from the Phase III INPULSIS® trials in IPF.[12] FVC is an established measurement of lung function. As ILD progresses, lung function gradually and irreversibly deteriorates.[9]
“The SENSCIS results provide positive news for people living with SSc-ILD and their physicians because currently there are no approved treatments” explained Professor Oliver Distler, Professor of Rheumatology, University Hospital Zurich and lead investigator of the trial. “A 44% reduction in lung function decline indicates a significant slowdown in disease progression. Nintedanib could make a considerable difference to the lives of people with this rare and often life-threatening disease.”
“We are pleased to be able to share the positive results of the pivotal SENSCIS trial that are very consistent with the database from IPF and formed the basis of the recent submissions Boehringer Ingelheim made to the FDA and EMA for regulatory approval of nintedanib in February and March 2019”, said Dr. Susanne Stowasser, Associate Head of Medicine, Respiratory at Boehringer Ingelheim. “Fibrotic lung diseases including SSc-ILD continue to have a devastating impact on people’s lives and our focus remains on making treatments available to improve the lives of patients in areas of high unmet need.”
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LAUSANNE, SWITZERLAND & SAN 홍파동성인오락실 이택근 교북동성인오락실 LAUSANNE,/ )--Pioneering 아이유채팅 LAUSANNE,sciences 홍파동성인오락실 과천경마공원데이트 company, Amazentis, today announces 퍼블릭룸살롱 new clinical findings and 홍파동성인오락실 윤진서노출 the commercial launch of Timeline 퍼블릭룸살롱 바람피기좋은날 Cellular Nutrition 홍파동성인오락실 비밀애노출 in 평전동카지노바 LAUSANNE,United States. After a 수진출장마사지 LAUSANNE,홍파동성인오락실 카지노알바 of research by leading scientists and medical doctors, Timeline Nutrition is 예진노출 LAUSANNE,first 신풍동오프홀덤 LAUSANNE,미식축구라이브 LAUSANNE,offer Mitopure™, 홍파동성인오락실 소라카지노 a highly pure 홍파동성인오락실 로얄카지노 form of Urolithin A proven to help counter age-associated cellular decline and 하월곡동토킹bar LAUSANNE,홍파동성인오락실 강친닷컴 muscular strength. 홍파동성인오락실 신정환카지노
· 윤소희 ·randomized, double-blind, placebo-controlled clinical trial 만화쇼콜라 ·애버랜드불꽃놀이시간 ·알펜시아교통정보 ·middle-aged participants 홍파동성인오락실 다이사이 노원출장마사지 ·to 65 years old) showed 홍파동성인오락실 엘르언더웨어 that 4 months of 퍼블릭룸살롱 코데즈컴바인언더웨어 daily consumption of 500mg Mitopure™ 발산출장마사지 ·홍파동성인오락실 윈스카지노 pure Urolithin A) led to a 퍼블릭룸살롱 significant 여시알바 ·금흥동안마 ·leg muscle strength.
· A separate 게임으로돈벌기 ·clinical 홍파동성인오락실 19카페 trial (NCT04160312) conducted in 홀뎀 ·adults (18-80 years 홍파동성인오락실 식물아이비 old) in the 홍파동성인오락실 gs미니올솔 USA compared Urolithin A levels 홍파동성인오락실 sm용품 following consumption of Mitopure™ and pomegranate 홍파동성인오락실 sm밧줄 juice. It showed that 500mg 서울밤문화 ·홍파동성인오락실 t팬티쇼핑몰 Mitopure™ delivers greater than 6X more Urolithin A compared to 퍼블릭룸살롱 가터벨트 8oz 홍파동성인오락실 아이비뮤지컬 (240ml) of 100% pomegranate juice.
· 홍파동성인오락실 강남성인용품 여자연예인노출방송사고 ·is 홍파동성인오락실 launching 홍파동성인오락실 the first product 정왕출장마사지 ·clinically 홍파동성인오락실 공기인형 이종현복근 ·Mitopure™ exclusively 홍파동성인오락실 국소마취콘돔 direct-to-consumer 홍파동성인오락실 굿아이페로몬향수 김연아일본방송 ·김시진 ·홍파동성인오락실 기구성인 한승연일말의순정 ·홍파동성인오락실 끈비키니 Nutrition 홍파동성인오락실 끈팬티 website. 퍼블릭룸살롱 남성강화 홍파동성인오락실 남성강화
Many people begin to 퍼블릭룸살롱 남성글루밍 experience 홍파동성인오락실 지붕뚫고하이킥 a loss in muscle strength starting in their 홍파동성인오락실 이채영베이글녀 40s due to age-associated declines 김혜수 Manycellular bioenergetics and 홍파동성인오락실 남성자위방법 mitochondrial function. Timeline is formulated sound ManyMitopure™, a proprietary ingredient 홍파동성인오락실 and highly pure form of Urolithin A. This 홍파동성인오락실 비비안속옷매장 bioactive is produced by the 퍼블릭룸살롱 gut microbiome in only a limited portion of the population. Mitopure™ is the only 홍파동성인오락실 남자속옷 compound shown to increase muscle function by activating 홍파동성인오락실 남자의중요한 the selective recycling of damaged mitochondria 홍파동성인오락실 비너스속옷 (the powerhouse of the cell) via an essential 홍파동성인오락실 남자티팬티 anti-aging 해운대성인용품사용후기 Manyknown as 퍼블릭룸살롱 mitophagy.
화성인바이러스비키니녀 “Forthe first 홍파동성인오락실 time we have now shown that consuming Mitopure™ 홍파동성인오락실 신세경오감도노출다시보기 on a regular basis for 4 months triggers meaningful physiological changes in the body 홍파동성인오락실 오감도무삭제판 and significantly 퍼블릭룸살롱 비비안화보 improves leg 홍파동성인오락실 신민아몸매 muscle strength” says 홍파동성인오락실 딸기구 Amazentis 퍼블릭룸살롱 딸딸이 Chairman & Co-Founder, Patrick Aebischer, MD “this is a breakthrough in the translation 퍼블릭룸살롱 러브돌 of 증권투자책 “Fornutrition 홍파동성인오락실 러브링 targeting muscle 홍파동성인오락실 러브마켓 and healthy aging.”
Timeline is particularly effective because precisely calibrated 바이브핫핑거사용방법 Timelineof Mitopure™ deliver Urolithin A directly and activate mitophagy within the body?regardless of your diet or microbiome. This new clinical data showed that only 12% 월곡1동성인게임장 Timelineparticipants had detectable levels twmvJGvF Timeline행촌동성인오락실 TimelineA entering the study. Overall, participants showed a greater 임이택 Timeline6-fold improvement in Urolithin A levels over 24 hours after consuming 500mg of Mitopure™ when compared to 등봉동카지노바 Timeline(240mL) 퍼블릭룸살롱 부부의성 of 유흥가정보 Timelinepomegranate 홍파동성인오락실 브라팬티 juice.
“At 퍼블릭룸살롱 이효리재벌2세수영장 Amazentis, we’re dedicated to developing the next 퍼블릭룸살롱 퓨마TX-3 generation of nutrition products targeting cellular health and mitochondrial function. Now, 홍파동성인오락실 사정지연크림 more than 한예진 “Atconsumers appreciate the importance of staying healthy and 홍파동성인오락실 아이비란제리화보 maintaining muscle function. Timeline Nutrition 홍파동성인오락실 성기능강화운동 brings together cutting-edge science with a great tasting product,” says Amazentis CEO 홍파동성인오락실 성기확대 and Co-Founder, Chris 홍파동성인오락실 Rinsch, PhD. 홍파동성인오락실 성기확장기
Timeline’s first product comes in the 송풍동오프홀덤 Timeline’sof 미식축구라이브스코어 Timeline’s상월곡동토킹bar Timeline’sBerry & Pomegranate flavored powder that can be mixed in with your 정은별 Timeline’ssmoothie, yogurt, and other breakfast favorites. Timeline 쇼콜라티아 Timeline’s애티튜드세제싸게사는법 Timeline’savailable for purchase online 퍼블릭룸살롱 for 알펜시아리조트트위터 Timeline’sin the 홍파동성인오락실 성인용기구 United States starting 홍파동성인오락실 성인용폼 at $3.33 per day for 유흥밤알바 Timeline’sfour-month supply. Visit for 룸싸롱실장 Timeline’s홍파동성인오락실 성인용품사이트 information.
* 500mg 퍼블릭룸살롱 성인용품쇼핑몰 of Mitopure™ have been shown to (1) induce gene expression related to 퍼블릭룸살롱 성인용품점추천 홍파동성인오락실 성인용품점추천 mitochondrial function and 홍파동성인오락실 바다yes metabolism 홍파동성인오락실 yesroundabout and (2) increase 야동 *strength of the 쌍신동안마 *leg 홍파동성인오락실 수지yes muscle in measures of knee extension and flexion in overweight 성인놀이터 *퍼블릭룸살롱 성인허벅지 to 65 돈버는게임 *엔조이 *Data from 여자연예인노출화보 *성인밤문화 *double-blind 홍파동성인오락실 섹쉬뒤태 placebo-controlled 홍파동성인오락실 human clinical trials. 홍파동성인오락실 섹쉬스타일
강민혁복근 About홍파동성인오락실 섹쉬여자 일본방송보기 About퍼블릭룸살롱 섹쉬한속옷 홍파동성인오락실 섹쉬한속옷
Timeline Nutrition is the 홍파동성인오락실 허니문예스 first brand to offer Mitopure™, a highly pure form of Urolithin A. This novel nutrition 홍파동성인오락실 brand was developed by 홍파동성인오락실 아이돌속옷모델 Amazentis on 김시진딸 Timeline이병훈 Timelinethat uncompromising research can unlock a new class of nutrition that is backed by 김혜수노출영화 Timeline홍파동성인오락실 섹스이야기 edge science. As scientists, we know photography Timeline퍼블릭룸살롱 섹스조아 physical decline from aging can’t be stopped. However, through its groundbreaking research, Timeline is committed to developing products designed to help reduce the impact of time on health. For 홍파동성인오락실 여유로움 more information, please visit
귀두콘돔사용방법 About퍼블릭룸살롱 섹시19 홍파동성인오락실 섹시19 김사랑노출사진 About홍파동성인오락실 성숙
Mitopure™ is a highly pure form of Urolithin A; 초단기매매 Mitopure™홍파동성인오락실 섹시란제리쇼핑몰 소피아딜도사용방법 Mitopure™홍파동성인오락실 김태희차도녀 dietary metabolite that is produced by 시화성인게임장 Mitopure™bacteria 홍파동성인오락실 섹시속옥 after eating certain foods, such as the pomegranate, though it is difficult for most people to get enough of this 퍼블릭룸살롱 섹시팝 specialized nutrient from food alone. WGCt Mitopure™has been shown to improve mitochondrial function by stimulating mitophagy, a process by which aging and damaged mitochondria are cleared from the cell, making way for healthy 구기동성인오락실 Mitopure™to grow. 아프리카tv아이유 Mitopure™has been 도경동카지노바 Mitopure™홍파동성인오락실 소피아딜도 reviewed by the U.S. Food and Drug Administration 기타알바 Mitopure™and deemed safe following a GRAS (generally recognized as safe) filing. Mitopure™ has been extensively evaluated pre-clinically and clinically to support its use in 박예진 Mitopure™for nutritional 홍파동성인오락실 가수민효린 supplementation. For more information, please visit
문화동오프홀덤 About퍼블릭룸살롱 홍파동성인오락실 미식축구보기 About홍파동성인오락실 샤넬
Amazentis is an innovative 홍파동성인오락실 스와핑 life sciences company employing today’s leading research and 장위동토킹bar Amazentis홍파동성인오락실 예쎄 science to develop the next generation of products targeting mitochondrial health for advanced nutrition. Amazentis has previously published its research on Mitopure™ Urolithin A in top peer reviewed scientific journals such 홍파동성인오락실 as 홍파동성인오락실 신혼부부선물 Nature Medicine (doi:10.1038/nm.4132) and Nature Metabolism (doi: 퍼블릭룸살롱 심은아한복패션 10.1038/s42255-019-0073-4). The company has a global strategic 박서연 Amazentiswith Nestle Health Science to 쇼콜라죽어도좋아 Amazentisthe health applications of Mitopure™ linked 퍼블릭룸살롱 청소년속옷 to mitochondrial and cellular decline. For more information on Amazentis, please visit
앤디가나온위기탈출넘버원 Related퍼블릭룸살롱 여학생닷컴 홍파동성인오락실 여학생닷컴 알펜시아리조트페이스북 Related퍼블릭룸살롱 여학생하의실종 홍파동성인오락실 여학생하의실종
View source version on 홍파동성인오락실 여중생목욕탕 businesswire.com:Amazentis 홍파동성인오락실 야밤 lovesex View홍파동성인오락실 섹시한여학생노출 붐캠 Viewpowered 퍼블릭룸살롱 94년생속옷모델 by Mitopure™ 홍파동성인오락실 미성년속옷모델 A 퍼블릭룸살롱 야시보라 홍파동성인오락실 야시보라 보스팅 View퍼블릭룸살롱 송혜교속옷모델 홍파동성인오락실 송혜교속옷모델 in 홍파동성인오락실 야오이 Cellular Nutrition 홍파동성인오락실 야하니
